The Packers are looking for their second win in three games against the Saints and are looking to continue their season sweep of New Orleans with a 27-16 win over the Saints.
The Packers (2-1) held the Saints (1-1), who lost linebacker Jairus Byrd, to a season-high 17 sacks and tied their season low for points allowed with seven.
New Orleans was without starting running back Chris Ivory (concussion) and receiver Keenan Lewis (knee).
The Packers had two first downs and two turnovers before Brees connected with Brandon LaFell for a 38-yard touchdown pass to James Jones on the game-winning drive.
New York has won eight straight at home against the Falcons and the Saints have won seven of their last eight games.
New England has won two of the last three meetings with the Packers, including the 2014 season-opening win.
This is the second time in five games the Saints are without a starting quarterback.
Brees has completed 67.9 percent of his passes for 4,086 yards with 16 touchdowns and seven interceptions.
The Saints lost guard Evan Mathis (shoulder) to a knee injury in the first half.
The Patriots have scored 25 touchdowns and allowed seven touchdowns.
They are coming off a 17-16 victory over the Atlanta Falcons on Sunday.
The Falcons held New England to 31 points in the fourth quarter, including 11 of their final 19 points in that period.
They held the Patriots to 38 yards on 18 carries, averaging 5.8 yards per carry.
Falcons wide receiver Julio Jones caught all 12 of his targets for 122 yards and a touchdown.
He caught five passes for 68 yards.
The team also had seven sacks.
Jones has played in all 12 games.
The Green Bay defense is allowing 31.9 points per game.
This was the fourth time this season the Saints rank in the bottom 10 in total defense and allowed the fewest points per contest (24.7).
New Orleans has allowed 17 or more points in five of its last six games.
Brees completed 13 of 28 passes for 212 yards and three touchdowns.
He was sacked eight times, including five times in the third quarter.